Wednesday, 20th September 2017
Senegal
France
Germany
The Netherlands
United Kingdom

Work package 1

Clinical trials “Efficacy of Favipiravir (T705) in reducing mortality in adults at early stage of Ebola Virus Disease in Guinea: a phase IIb trial

The primary objective of this workpackage is to assess the efficacy of high-dose Favipiravir in decreasing mortality in adults with EVD who start treatment early.
The secondary objectives are: to assess the efficacy of Favipiravir in decreasing plasma RNA and infectious loads; to assess the tolerance of the drug; and to describe the evolution of viral subpopulations of EBOV (including the analysis of mutations potentially associated with antiviral resistance) using deep sequencing approaches.

Involved institutions
ADERA (France):
Prof. Denis Malvy (WP lead)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (France):
Prof. France Mentré (co-lead), Prof. Hervé Raoul

UNIVERSITE D'AIX MARSEILLE (France):
Prof. Xavier De Lamballerie (WP co-lead)

INSTITUT PASTEUR (France):
Dr. Sylvain Baize